Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.

@article{Siendones2014MembraneboundCI,
  title={Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.},
  author={Emilio Siendones and Sara SantaCruz-Calvo and Alejandro Mart{\'i}n-Montalvo and Maria Victoria Cascajo and Julia Raquel Meneses Ariza and Guillermo L{\'o}pez-Lluch and J. M. Villalba and C{\'e}cile Acquaviva-Bourdain and Emmanuel Roze and Michel Bernier and Rafael de Cabo and Pl{\'a}cido Navas},
  journal={Antioxidants & redox signaling},
  year={2014},
  volume={21 12},
  pages={
          1708-25
        }
}
AIMS Membrane-bound CYB5R3 deficiency in humans causes recessive hereditary methaemoglobinaemia (RHM), an incurable disease that is characterized by severe neurological disorders. CYB5R3 encodes for NADH-dependent redox enzyme that contributes to metabolic homeostasis and stress protection; however, how it is involved in the neurological pathology of RHM remains unknown. Here, the role and transcriptional regulation of CYB5R3 was studied under nutritional and oxidative stress. RESULTS CYB5R3… CONTINUE READING
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