Membrane bound α-synuclein is fully embedded in the lipid bilayer while segments with higher flexibility remain.


Cellular pathways involving α-synuclein (αS) seem to be causative for development of Parkinson's disease. Interactions between αS and lipid membranes appear to be important for the physiological function of the protein and influence the pathological aggregation of αS leading to the formation of amyloid plaques. Upon membrane binding the unstructured αS… (More)
DOI: 10.1016/j.febslet.2013.06.034