• DOI:10.1038/35070009
Corpus ID: 2537726

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

@article{Coleman2001MembraneBD,
  title={Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I},
  author={M. Coleman and E. Sahai and M. Yeo and M. Bosch and A. Dewar and M. Olson},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={339-345}
}

• M. Coleman, E. Sahai, +3 authors M. Olson
• Published 2001
• Biology, Medicine
• Nature Cell Biology

The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. The actin–myosin system has been proposed to be the source of contractile force that drives bleb formation, although the biochemical pathway that promotes actin–myosin contractility during apoptosis has not been identified. Here we show that the Rho effector protein ROCK I, which contributes to phosphorylation of myosin light-chains, myosin ATPase activity and… Expand

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