Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

@article{Coleman2001MembraneBD,
  title={Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I},
  author={Mathew L. Coleman and Erik Sahai and Margaret Yeo and Marta Bosch and Ann Dewar and Michael F. Olson},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={339-345}
}
The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. The actin–myosin system has been proposed to be the source of contractile force that drives bleb formation, although the biochemical pathway that promotes actin–myosin contractility during apoptosis has not been identified. Here we show that the Rho effector protein ROCK I, which contributes to phosphorylation of myosin light-chains, myosin ATPase activity and… 
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