Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

@article{Coleman2001MembraneBD,
  title={Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I},
  author={M. Coleman and E. Sahai and M. Yeo and M. Bosch and A. Dewar and M. Olson},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={339-345}
}
The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. The actin–myosin system has been proposed to be the source of contractile force that drives bleb formation, although the biochemical pathway that promotes actin–myosin contractility during apoptosis has not been identified. Here we show that the Rho effector protein ROCK I, which contributes to phosphorylation of myosin light-chains, myosin ATPase activity and… Expand
1,110 Citations
ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton.
  • 44
Actin-myosin–based contraction is responsible for apoptotic nuclear disintegration
  • 181
  • PDF
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.
  • 81
Cytoskeleton and apoptosis.
  • 160
Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells.
  • 38
  • Highly Influenced
  • PDF
Myosin light chain kinase plays a role in the regulation of epithelial cell survival
  • 52
  • PDF
Cell motility through plasma membrane blebbing
  • 532
  • PDF
RhoA signaling in phorbol ester-induced apoptosis.
  • 13
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation
  • 472
  • PDF
The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing.
  • 96
  • PDF
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
  • 2,796
Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase
  • 1,079
...
1
2
3
4
...