Membrane bleb: A seesaw game of two small GTPases.

  title={Membrane bleb: A seesaw game of two small GTPases.},
  author={Junichi Ikenouchi and Kana Aoki},
  journal={Small GTPases},
  volume={8 2},
The plasma membrane is generally associated with underling actin cytoskeleton. When the plasma membrane detaches from actin filaments, it is expanded by the intracellular pressure and the spherical membrane protrusion which lacks underlying actin cortex, termed bleb, is formed. Bleb is widely used for migration across species; however, the molecular mechanism underlying membrane blebbing remains largely unknown. Our recent study revealed that 2 small GTPases, Rnd3 and RhoA, are important… CONTINUE READING
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