Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox.

@article{Stahelin2003MembraneBM,
  title={Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox.},
  author={Robert V. Stahelin and Aura Burian and Karol S. Bruzik and Diana Murray and Wonhwa Cho},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 16},
  pages={14469-79}
}
Phox (PX) domains are phosphoinositide (PI)-binding domains with broad PI specificity. Two cytosolic components of NADPH oxidase, p40(phox) and p47(phox), contain PX domains. The PX domain of p40(phox) specifically binds phosphatidylinositol 3-phosphate, whereas the PX domain of p47(phox) has two lipid binding sites, one specific for phosphatidylinositol 3,4-bisphosphate and the other with affinity for phosphatidic acid or phosphatidylserine. To delineate the mechanisms by which these PX… CONTINUE READING

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