Membrane-binding and enzymatic properties of RPE65

@article{Kiser2010MembranebindingAE,
  title={Membrane-binding and enzymatic properties of RPE65},
  author={Philip D Kiser and Krzysztof Palczewski},
  journal={Progress in Retinal and Eye Research},
  year={2010},
  volume={29},
  pages={428-442}
}
Regeneration of visual pigments is essential for sustained visual function. Although the requirement for non-photochemical regeneration of the visual chromophore, 11-cis-retinal, was recognized early on, it was only recently that the trans to cis retinoid isomerase activity required for this process was assigned to a specific protein, a microsomal membrane enzyme called RPE65. In this review, we outline progress that has been made in the functional characterization of RPE65. We then discuss… CONTINUE READING

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Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009
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