Membrane bending energy and fusion pore kinetics in Ca(2+)-triggered exocytosis.

  title={Membrane bending energy and fusion pore kinetics in Ca(2+)-triggered exocytosis.},
  author={Zhen Zhang and Meyer B Jackson},
  journal={Biophysical journal},
  volume={98 11},
A fusion pore composed of lipid is an obligatory kinetic intermediate of membrane fusion, and its formation requires energy to bend membranes into highly curved shapes. The energetics of such deformations in viral fusion is well established, but the role of membrane bending in Ca(2+)-triggered exocytosis remains largely untested. Amperometry recording showed that during exocytosis in chromaffin and PC12 cells, fusion pores formed by smaller vesicles dilated more rapidly than fusion pores formed… CONTINUE READING
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