Membrane bending by protein–protein crowding

@article{Stachowiak2012MembraneBB,
  title={Membrane bending by protein–protein crowding},
  author={Jeanne C Stachowiak and Eva M. Schmid and Christopher James Ryan and Hyoung Sook Ann and Darryl Yoshio Sasaki and Margaret B. Sherman and Phillip L. Geissler and Daniel A Fletcher and Carl C. Hayden},
  journal={Nature Cell Biology},
  year={2012},
  volume={14},
  pages={944-949}
}
Curved membranes are an essential feature of dynamic cellular structures, including endocytic pits, filopodia protrusions and most organelles. It has been proposed that specialized proteins induce curvature by binding to membranes through two primary mechanisms: membrane scaffolding by curved proteins or complexes; and insertion of wedge-like amphipathic helices into the membrane. Recent computational studies have raised questions about the efficiency of the helix-insertion mechanism… CONTINUE READING
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the amphiphysin BAR structure

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