Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.

Abstract

Are the dimer structures of active Ras isoforms similar? This question is significant since Ras can activate its effectors as a monomer; however, as a dimer, it promotes Raf's activation and MAPK (mitogen-activated protein kinase) cell signalling. In the present study, we model possible catalytic domain dimer interfaces of membrane-anchored GTP-bound K… (More)
DOI: 10.1042/BCJ20160031

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