Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail.

@article{Andersson2003MembraneAO,
  title={Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail.},
  author={Helena Andersson and Aaron M D'Antona and Debra A. Kendall and Gunnar von Heijne and Chen-ni Chin},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 3},
  pages={570-7}
}
The human cannabinoid receptor 1 (CB1) belongs to the G protein-coupled receptor (GPCR) family. Among the members of GPCR family, it has an exceptionally long extracellular N-terminal domain (N-tail) of 116 amino acids but has no typical signal sequence. This poses questions of how the long N-tail affects the biosynthesis of the receptor and of how it is inserted into the endoplasmic reticulum (ER) membrane. Here we have examined the process of membrane assembly of CB1 in the ER membrane and… CONTINUE READING
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