Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

@article{Papadopoulou2008MembraneAR,
  title={Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells},
  author={Natalia Papadopoulou and Ioannis Charalampopoulos and Vasileia Anagnostopoulou and Georgios Konstantinidis and Michael F{\"o}ller and Achille G. Gravanis and Konstantinos Alevizopoulos and Florian Lang and Constantine Stournaras},
  journal={Molecular Cancer},
  year={2008},
  volume={7},
  pages={88 - 88}
}
BackgroundRecently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling. In the present study we explored the specificity of these receptors and we analyzed downstream effectors controlling survival and apoptosis in hormone refractory DU145-prostate cancer cells stimulated with membrane androgen receptor-selective agonists.ResultsUsing membrane impermeable conjugates of serum albumin covalently linked to… CONTINUE READING
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