Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impact.

@article{Papadopoulou2009MembraneAR,
  title={Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impact.},
  author={Natalia Papadopoulou and Evangelia A. Papakonstanti and G Kallergi and Konstantinos Alevizopoulos and Constantine Stournaras},
  journal={IUBMB life},
  year={2009},
  volume={61 1},
  pages={
          56-61
        }
}
In recent years, membrane androgen receptors (mARs) have been identified in prostate and breast tumor cells, and their activation by specific mAR ligands was linked to the regulation of crucial cell responses, such as cell growth, motility, and apoptosis. Analysis of the molecular signals triggered by mAR in the presence of anti-androgens has clearly differentiated mAR-dependent biological actions from those induced by the activation of the classical intracellular androgen receptors (iARs). In… CONTINUE READING
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