Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.

@article{Tjwa2009MembraneanchoredUR,
  title={Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.},
  author={Marc Tjwa and Nicolai Sidenius and Rute Moura and Sandra Jansen and Koen Theunissen and Annapaola Andolfo and Maria de Mol and Mieke Dewerchin and Lieve Moons and Francesco D. Di Blasi and Catherine M. Verfaillie and Peter Carmeliet},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 4},
  pages={1008-18}
}
The mechanisms of BM hematopoietic stem/progenitor cell (HSPC) adhesion, engraftment, and mobilization remain incompletely identified. Here, using WT and transgenic mice, we have shown that membrane-anchored plasminogen activator, urokinase receptor (MuPAR) marks a subset of HSPCs and promotes the preservation of the size of this pool of cells in the BM. Loss or inhibition of MuPAR increased HSPC proliferation and impaired their homing, engraftment, and adhesion to the BM microenvironment… CONTINUE READING