Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta

@article{Andres1989MembraneanchoredAS,
  title={Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta},
  author={Janet L Andres and Kurt Stanley and Sela Cheifetz and Joan Massagu{\'e}},
  journal={The Journal of Cell Biology},
  year={1989},
  volume={109},
  pages={3137 - 3145}
}
Transforming growth factors beta 1 and beta 2 bind with high affinity to the core protein of a 250-350-kD cell surface proteoglycan. This proteoglycan (formerly referred to as the type III TGF-beta receptor) coexists in many cells with the receptor implicated in TGF-beta signal transduction (type I TGF-beta receptor), but its function is not known. We report here that soluble TGF-beta-binding proteoglycans are released by several cell types into the culture media, and can be found in serum and… CONTINUE READING