Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation

@article{Howlett2002MembraneanchoredCS,
  title={Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation},
  author={Christopher J. Howlett and Stephen M. Robbins},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={1707-1716}
}
The mammalian proto-oncogene Cbl and its cellular homologues in Caenorhabditis elegans (Sli-1) and Drosophila (D-Cbl) are negative regulators of some growth factor receptor signaling pathways. Herein we show that Cbl can negatively regulate another signaling molecule, namely theSrc-family kinase Hck by targeting it for degradation. Hck-mediated cellular transformation of murine fibroblasts is reverted by ectopic expression of a membrane-anchored allele of Cbl as assessed by the cellular… 

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