Membrane-anchored CD 40 Is Processed by the Tumor Necrosis Factor-- converting Enzyme IMPLICATIONS FOR CD 40 SIGNALING *

@inproceedings{Contin2003MembraneanchoredC4,
  title={Membrane-anchored CD 40 Is Processed by the Tumor Necrosis Factor-- converting Enzyme IMPLICATIONS FOR CD 40 SIGNALING *},
  author={C{\'e}cile Contin and Vincent Pitard and Toshimitsu Itai and Shigekazu Nagata and J-J. Moreau and Julie D{\'e}chanet-Merville},
  year={2003}
}
The soluble form of CD40 (sCD40), which co-exists with the membrane-anchored form (mCD40), is a natural antagonist of mCD40/CD154 interaction. However, the mechanism leading to the production of sCD40 has never been investigated. Here, we show that the engagement of mCD40 on the surface of B lymphocytes by antiCD40 antibody led to enhanced sCD40 release associated with decreased amounts of mCD40. This sCD40 production was not affected by vesicular traffic inhibitors but was completely blocked… CONTINUE READING

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References

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SHOWING 1-2 OF 2 REFERENCES

CD40 Processing by TNF- -converting Enzyme 32808 by gest, on Jne 29, 2011 w w w .jb.org D ow nladed fom munol

  • R. Xiang, F. J. Primus, +6 authors R. A. Reisfeld
  • 2001

562–567 Membrane-anchored CD40 Processing by TNF- -converting Enzyme 32809 by gest, on Jne 29

  • S. Braesch-Andersen, S. Paulie, H. Koho, H. Nika, P. Aspenström, P. Perlmann
  • J. Immunol
  • 1989

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