Membrane-active drugs potentiate the killing of tumor cells by D-glucosamine.

@article{Friedman1980MembraneactiveDP,
  title={Membrane-active drugs potentiate the killing of tumor cells by D-glucosamine.},
  author={Susan J. Friedman and Philip Skehan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 2},
  pages={
          1172-6
        }
}
  • Susan J. Friedman, Philip Skehan
  • Published 1980
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • D-Glucosamine is toxic to several malignant cell lines and in vivo tumors at concentrations that have little effect upon normal host tissues. Evidence is presented to support the hypothesis that cellular membranes may be the primary targets of glucosamine's tumoricidal activity. Treatment of rat C6 glioma cells with a cytotoxic concentration of glucosamine (20 mM) caused fragmentation of rough endoplasmic reticulum, proliferation of Golgi complexes, evagination of outer nuclear and… CONTINUE READING
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