Membrane Transporters and Channels

  title={Membrane Transporters and Channels},
  author={Ying Huang and Pascale Anderle and Kimberly J. Bussey and Catalin C. Barbacioru and Uma T. Shankavaram and Zunyan Dai and William C. Reinhold and Audrey C. Papp and John N. Weinstein and Wolfgang Sadee},
  journal={Cancer Research},
  pages={4294 - 4301}
Membrane transporters and channels (collectively the transportome) govern cellular influx and efflux of ions, nutrients, and drugs. We used oligonucleotide arrays to analyze gene expression of the transportome in 60 human cancer cell lines used by the National Cancer Institute for drug screening. Correlating gene expression with the potencies of 119 standard anticancer drugs identified known drug-transporter interactions and suggested novel ones. Folate, nucleoside, and amino acid transporters… 

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