Membrane Structure: Some General Principles

@article{Bretscher1973MembraneSS,
  title={Membrane Structure: Some General Principles},
  author={Mark S. Bretscher},
  journal={Science},
  year={1973},
  volume={181},
  pages={622 - 629}
}
  • M. Bretscher
  • Published 17 August 1973
  • Biology, Chemistry
  • Science
The arrangement of lipids and some proteins in the erythrocyte membrane has been discussed. The conclusions from this are listed here as a set of general guidelines for the structure of membranes of higher organisms: some of these rules may be wrong. But at this stage it seems useful to sharpen our thoughts in this way and thereby focus attention on various specific points. 1) The basis of a membrane is a lipid bilayer with (i) choline phospholipids and glycolipids in the external half and (ii… 

Membrane Proteins: Structure and Arrangement in the Membrane

The membranes of a cell have the principal function of setting the boundaries between the cell and the environment and between compartments within the cell. These boundaries prevent the movement of

The Dynamics Of Membrane Structur

The biosynthesis, turnover and modulation of the properties of interacting membrane constituents is critically reviewed and possible ways of controlling the behavior of cells and organisms by altering the structural parameters of different membranes has been considered.

THE ORGANIZATION OF PROTEINS IN THE HUMAN RED BLOOD CELL MEMBRANE

  • T. Steck
  • Biology
    The Journal of cell biology
  • 1974
This article will focus on the localization and modes of association of individual major polypeptides within the human red cell membrane.

Asymmetry of influenza virus membrane bilayer demonstrated with phospholipase C

The consistency between the present findings and pevious findings with red cell membranes suggest an asymmetric phospholipid distribution of this type may be a general feature of plasma membrane Structure.

Significance of minor glycerolipids in membrane structure and function.

There is a range of possible functions for individual membrane lipids which encompasses both the general and the highly specific; many of these protein-lipid interactions, and thus the functions of the proteins, are probably relatively constant over considerable periods.

Protein-liposome interactions and their relevance to the structure and function of cell membranes

The degree of correspondence between the behavior of model systems and natural membranes encourages the continuing use of model membranes in studies on protein-lipid interactions, but some of the data on the increase of surface pressure of phospholipid monolayers by proteins and increases in the permeability of liposomes indicate that many soluble proteins also have a capability to interact hydrophobically with phospholIPids.
...

References

SHOWING 1-10 OF 69 REFERENCES

GLOBULAR LIPID MICELLES AND CELL MEMBRANES.

  • J. Lucy
  • Biology, Chemistry
    Journal of theoretical biology
  • 1964

Dissolution of erythrocyte membranes in water and comparison of the membrane protein with other structural proteins.

  • D. MaziaA. Ruby
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1968
The nearly complete dissolution of the cell membranes of beef erythrocytes and the recovery of most of the protein in solution is described and it is suggested that there exists a genus of related proteins which are employed in the assembly of a variety of cell structures and the name tektins is proposed for the genus.

The Fluid Mosaic Model of the Structure of Cell Membranes

Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.

DISCUSSION PAPER: MEMBRANE PROTEINS

  • G. Guidotti
  • Biology
    Annals of the New York Academy of Sciences
  • 1972
It is found that a variety of procedures can fractionate the membrane of the erythrocyte with identical results: namely, the membrane breaks up into small vesicles with the liberation of about 10-20% of the proteins free of lipid or carbohydrate components.

Structure of Biological Membranes

  • E. Korn
  • Chemistry, Biology
    Science
  • 1966
The combined x-ray diffraction and electron microscopic examination of myelin has provided reasonable, but not conclusive, support for its structure as a basically bimolecular leaflet of phospholipid

Biological membrane structure, I. The protein crystal model for membranes.

  • G. VanderkooiD. E. Green
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1970
A geometric model for the arrangement of phospholipid and protein in biological membrane systems has been proposed and all the lipid known to be present in membranes can be accommodated in this manner.

On the biological role of glycoproteins.

  • E. Eylar
  • Biology
    Journal of theoretical biology
  • 1966

Red cell membrane glycoprotein: amino acid sequence of an intramembranous region.

...