Membrane Shape at the Edge of the Dynamin Helix Sets Location and Duration of the Fission Reaction

@article{Morlot2012MembraneSA,
  title={Membrane Shape at the Edge of the Dynamin Helix Sets Location and Duration of the Fission Reaction},
  author={Sandrine Morlot and Valentina Galli and Marius Klein and Nicolas Chiaruttini and J. J. Manzi and Fr{\'e}d{\'e}ric Humbert and Luis Dinis and Martin Lenz and Giovanni Cappello and Aur{\'e}lien Roux},
  journal={Cell},
  year={2012},
  volume={151},
  pages={619-629}
}
The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocytic pits to promote their fission. However, the dynamin mechanism is still debated because constriction is necessary but not sufficient for fission. Here, we show that fission occurs at the interface between the dynamin coat and the uncoated membrane. At this location, the considerable change in membrane curvature increases the local membrane elastic energy, reducing the energy barrier for fission… CONTINUE READING

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