Membrane Raft Disruption Promotes Axonogenesis in N2a Neuroblastoma Cells

  title={Membrane Raft Disruption Promotes Axonogenesis in N2a Neuroblastoma Cells},
  author={Kimberly A. Petro and C. -L. Schengrund},
  journal={Neurochemical Research},
Membrane rafts are discrete microdomains found in cell membranes that contain cholesterol and glycosphingolipids such as gangliosides. As cholesterol is a major component of membrane rafts, its sequestration by the polyene filipin can be used to disrupt them. In previous work we observed that membrane raft disruption by filipin treatment of murine neuroblastoma N2a cells led to changes in expression of cell processes. In this study, we determined the type of process formation induced by filipin… CONTINUE READING

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