Membrane Protein Structure Prediction Hydrophobicity Analysis and the Positive-inside Rule

@inproceedings{Gunnar2003MembranePS,
  title={Membrane Protein Structure Prediction Hydrophobicity Analysis and the Positive-inside Rule},
  author={Gunnar and von Heijne},
  year={2003}
}
  • Gunnar, von Heijne
  • Published 2003
A new strategy for predicting the topology of bacterial inner membrane proteins is proposed on the basis of hydrophobicity analysis, automatic generation of a set of possible topologies and ranking of these according to the positive-inside rule. A straightforward implementation with no attempts at optimization predict’s the correct topology for 23 out of 24 inner membrane proteins with experimentally determined topologies, and cborrectly identifies 135 transmembrane segments with only one… CONTINUE READING

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