Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex

@inproceedings{Zhu2011MembranePM,
  title={Membrane Potential-Dependent Modulation of Recurrent Inhibition in Rat Neocortex},
  author={Jie Zhu and Man Jiang and Mingpo Yang and Han Hou and Yousheng Shu},
  booktitle={PLoS biology},
  year={2011}
}
Dynamic balance of excitation and inhibition is crucial for network stability and cortical processing, but it is unclear how this balance is achieved at different membrane potentials (V(m)) of cortical neurons, as found during persistent activity or slow V(m) oscillation. Here we report that a V(m)-dependent modulation of recurrent inhibition between pyramidal cells (PCs) contributes to the excitation-inhibition balance. Whole-cell recording from paired layer-5 PCs in rat somatosensory cortical… CONTINUE READING

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