Membrane Localization and Rapid Non-Transcriptional Action of the Androgen Receptor

@inproceedings{Mink2003MembraneLA,
  title={Membrane Localization and Rapid Non-Transcriptional Action of the Androgen Receptor},
  author={S. Mink and L. Shatkina and A. Nestl and A. Cato},
  year={2003}
}
Androgens play a major role in male sexual development and in prostate growth during later life (for a review, see Brinkman 2001). They function by binding a cytoplasmic androgen receptor (AR) that is present in target cells in an inactive state in association with molecular chaperones and co-chaperones. Upon hormone binding, the receptor is thought to dissociate from the inactivating proteins and is transported into the nucleus where it binds discrete nucleotide sequences to modulate the… Expand
1 Citations
Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation
TLDR
Results suggest that ARs may serve as both a genomic and non-genomic transducer of androgen action in the hippocampal formation. Expand

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