Membrane Glycoprotein M6B Interacts with the Human Serotonin Transporter

  title={Membrane Glycoprotein M6B Interacts with the Human Serotonin Transporter},
  author={Anja Winther Fjorback and Heidi Kaastrup M{\"u}ller and Ove Wiborg},
  journal={Journal of Molecular Neuroscience},
The serotonin transporter (SERT) belongs to a family of sodium- and chloride-dependent neurotransmitter transporters that are responsible for the active re-uptake of the neurotransmitter serotonin from the synapse. In the present study, using the yeast two-hybrid system, we identified the membrane glycoprotein M6B as a binding partner of SERT. This interaction was further verified by co-immunoprecipitation and glutathione-S-transferase pull-down assays. M6B belongs to a proteolipid protein… CONTINUE READING