Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease.

@article{Sozio2013MemantinesulfurCA,
  title={Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease.},
  author={Piera Sozio and Laura Serafina Cerasa and Sara Laserra and Ivana Cacciatore and Catia Cornacchia and Ester Sara Di Filippo and Stefania Fulle and Antonella Fontana and Antonello di Crescenzo and Massimo Grilli and Mario D. De Marchi and Antonio di Stefano},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2013},
  volume={49 2},
  pages={187-98}
}
The approved treatments for Alzheimer's disease (AD) exploit mainly a symptomatic approach based on the use of cholinesterase inhibitors or N-methyl-D-aspartate (NMDA) receptor antagonists. Natural antioxidant compounds, able to pass through the blood-brain barrier (BBB), have been extensively studied as useful neuroprotective agents. A novel approach… CONTINUE READING