Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats

@inproceedings{Tucci2014MemantinePM,
  title={Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats},
  author={Paolo Tucci and Emanuela Mhillaj and Maria Grazia Morgese and Marilena Colaianna and Margherita Zotti and Stefania Schiavone and Maria Cicerale and Viviana Trezza and Patrizia Campolongo and Vincenzo Cuomo and Luigia Trabace},
  booktitle={Front. Behav. Neurosci.},
  year={2014}
}
It has been well documented that β-amyloid (Aβ) peptide accumulation and aggregation in the brain plays a crucial role in the pathophysiology of Alzheimer's disease (AD). However, a new orientation of the amyloid cascade hypothesis has evidenced that soluble forms of the peptide (sAβ) are involved in Aβ-induced cognitive impairment and cause rapid disruption of the synaptic mechanisms underlying memory. The primary aim of this study was to elucidate the effects of sAβ, acutely injected… CONTINUE READING

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