Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial.

@article{Boxer2013MemantineIP,
  title={Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial.},
  author={Adam L. Boxer and David S. Knopman and Daniel I. Kaufer and Murray Grossman and Chiadi Onyike and Neill Graf-Radford and Mario Anselmi Mendez and Diana R. Kerwin and Alan Lerner and C Wu and Mary E Koestler and Jill S Shapira and Kathryn A Sullivan and Kristen M. Klepac and Kristine Lipowski and Jerin Ullah and Scott Fields and Joel H. Kramer and Jennifer Merrilees and John M Neuhaus and Marek Marsel Mesulam and Bruce L. Miller},
  journal={The Lancet. Neurology},
  year={2013},
  volume={12 2},
  pages={149-56}
}
BACKGROUND Memantine has been used off-label to treat frontotemporal lobar degeneration (FTD). A previous 26-week open-label study suggested a transient, modest benefit on neuropsychiatric symptoms as measured by the neuropsychiatric inventory (NPI). We aimed to determine whether memantine is an effective treatment for FTD. METHODS We did a randomised, parallel group, double-blind, placebo-controlled trial of 20 mg memantine taken orally daily for 26 weeks in patients with FTD. Participants… CONTINUE READING
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