Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina.

@article{Ju2009MemantineBM,
  title={Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina.},
  author={W Ju and K. Kim and Mila Angert and Karen X. Duong-Polk and James Lindsey and Mark H. Ellisman and Robert N. Weinreb},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 2},
  pages={707-16}
}
PURPOSE To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHODS Preglaucomatous DBA/2J mice received memantine (5 mg/kg, intraperitoneal injection, twice daily for 3 months) and IOP in the eyes was measured monthly. RGC loss was counted… CONTINUE READING

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