Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones.

@article{Wild2013MemantineBD,
  title={Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones.},
  author={Angela R Wild and Ethem Akyol and S L C Brothwell and P Kimkool and Jeremy N. Skepper and Alasdair J Gibb and Susan J. Jones},
  journal={Neuropharmacology},
  year={2013},
  volume={73},
  pages={138-46}
}
NMDA glutamate receptors (NMDARs) have critical functional roles in the nervous system but NMDAR over-activity can contribute to neuronal damage. The open channel NMDAR blocker, memantine is used to treat certain neurodegenerative diseases, including Parkinson's disease (PD) and is well tolerated clinically. We have investigated memantine block of NMDARs in substantia nigra pars compacta (SNc) dopamine neurones, which show severe pathology in PD. Memantine (10 μM) caused robust inhibition of… CONTINUE READING