Memantine-associated reversal of clozapine-induced weight gain.

  title={Memantine-associated reversal of clozapine-induced weight gain.},
  author={Martin Schaefer and Kathryn Leopold and Axel Hinzpeter and Andreas Heinz and Michael A. Krebs},
  volume={40 4},
INTRODUCTION Weight gain is a frequently observed adverse event in the treatment with atypical antipsychotics that significantly affects the patients' physical health and treatment compliance. METHODS We report on a treatment-resistant schizophrenic patient who received an add-on treatment with the low-affinity NMDA antagonist memantine because of cognitive disturbances. RESULTS During this treatment we observed a marked decrease of clozapine-induced weight gain. The causal relationship to… CONTINUE READING