Memantine agonist action at dopamine D2High receptors.

  title={Memantine agonist action at dopamine D2High receptors.},
  author={Philip Seeman and Carla Caruso and Mercedes Lasaga},
  volume={62 2},
Memantine is reported to improve symptoms in moderate cases of Alzheimer's disease and Parkinson's disease, but is also known to trigger psychosis in some Parkinson patients. Because these clinical features suggested a possible dopamine component of memantine action, we measured the potency of memantine on the functional high-affinity state of dopamine D2 receptors, or D2(High). Using [(3)H]domperidone to label D2 receptors, the memantine dissociation constant at D2(High) was 917 +/- 23 nM for… CONTINUE READING
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