Memantine agonist action at dopamine D2High receptors

  title={Memantine agonist action at dopamine D2High receptors},
  author={P. Seeman and C. Caruso and M. Lasaga},
  • P. Seeman, C. Caruso, M. Lasaga
  • Published 2008
  • Chemistry, Medicine
  • Synapse
  • Memantine is reported to improve symptoms in moderate cases of Alzheimer's disease and Parkinson's disease, but is also known to trigger psychosis in some Parkinson patients. Because these clinical features suggested a possible dopamine component of memantine action, we measured the potency of memantine on the functional high‐affinity state of dopamine D2 receptors, or D2High. Using [3H]domperidone to label D2 receptors, the memantine dissociation constant at D2High was 917 ± 23 nM for rat… CONTINUE READING
    91 Citations
    Is Memantine Effective as an NMDA Receptor Antagonist in Adjunctive Therapy for Schizophrenia?
    • 1
    • PDF
    Management of moderate to severe Alzheimer's disease: focus on memantine.
    • 14
    Psychotomimetic-like behavioral effects of memantine in the mouse.
    • 2
    Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line
    • 3
    • PDF


    Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum
    • 42
    Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics
    • 162
    • PDF
    Dopamine agonist action of phencyclidine
    • 27
    • PDF
    Neuropharmacological studies on D145 (1,3-dimethyl-5-aminoadamantan)
    • 31