Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons

@article{Aracava2005MemantineB,
  title={Memantine Blocks $\alpha$7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons},
  author={Yasco Aracava and Edna F. R. Pereira and Alfred Maelicke and Edson X. Albuquerque},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={312},
  pages={1195 - 1205}
}
The N-methyl-d-aspartate (NMDA) receptor antagonist memantine is an approved drug for treatment of Alzheimer's disease (AD). Other such treatments are cholinesterase inhibitors and nicotinic acetylcholine receptor (nAChR)-sensitizing agents such as galantamine. The present study was designed to test whether memantine exerts any effect on the cholinergic system, in particular the Ca2+-conducting α7* nAChR, in cultured hippocampal neurons. Memantine caused a concentration-dependent reduction of… 

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Response: Comments on “Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-d-aspartate Receptors in Rat Hippocampal Neurons”

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The clinical findings and the presently available preclinical data on the inhibitory actions of memantine in the nicotinic cholinergic system in the brain suggest that the prospect of using this drug for treatment of mild-to-moderate AD should be examined with a great deal of awareness and caution.

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