Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons

@article{Aracava2005MemantineB,
  title={Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons},
  author={Y. Aracava and E. Pereira and A. Maelicke and E. Albuquerque},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={312},
  pages={1195 - 1205}
}
  • Y. Aracava, E. Pereira, +1 author E. Albuquerque
  • Published 2005
  • Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • The N-methyl-d-aspartate (NMDA) receptor antagonist memantine is an approved drug for treatment of Alzheimer's disease (AD). Other such treatments are cholinesterase inhibitors and nicotinic acetylcholine receptor (nAChR)-sensitizing agents such as galantamine. The present study was designed to test whether memantine exerts any effect on the cholinergic system, in particular the Ca2+-conducting α7* nAChR, in cultured hippocampal neurons. Memantine caused a concentration-dependent reduction of… CONTINUE READING
    152 Citations

    Figures from this paper

    Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer's Disease
    • 23
    • PDF
    Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta
    • 29
    Cholinergic direct inhibition of N‐methyl‐D aspartate receptor‐mediated currents in the rat neocortex
    • 13
    Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine
    • 191
    • Highly Influenced
    • PDF
    Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology
    • 124
    • PDF

    References

    SHOWING 1-10 OF 55 REFERENCES
    Open-Channel Blockers at the Human α4β2 Neuronal Nicotinic Acetylcholine Receptor
    • 159
    • Highly Influential
    • PDF
    The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence
    • 333
    • Highly Influential
    • PDF
    The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.
    • 314
    • Highly Influential
    • PDF
    Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.
    • 567
    Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells.
    • 43
    • Highly Influential
    • PDF
    Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism.
    • 257
    • Highly Influential
    Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man
    • 154
    • Highly Influential