Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons

@article{Aracava2005MemantineB,
  title={Memantine Blocks $\alpha$7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons},
  author={Y. Aracava and E. Pereira and A. Maelicke and E. Albuquerque},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={312},
  pages={1195 - 1205}
}
The N-methyl-d-aspartate (NMDA) receptor antagonist memantine is an approved drug for treatment of Alzheimer's disease (AD). Other such treatments are cholinesterase inhibitors and nicotinic acetylcholine receptor (nAChR)-sensitizing agents such as galantamine. The present study was designed to test whether memantine exerts any effect on the cholinergic system, in particular the Ca2+-conducting α7* nAChR, in cultured hippocampal neurons. Memantine caused a concentration-dependent reduction of… Expand
Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer's Disease
Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta
Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine
Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology
  • M. Pohanka
  • Medicine
  • International journal of molecular sciences
  • 2012
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence
The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.
Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism.
Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man
...
1
2
3
4
5
...