Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase

@inproceedings{Huang2015MemantineAD,
  title={Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase},
  author={Chih-Yuan Huang and Liang-Chao Wang and Yan-Shen Shan and Chia-Hsin Pan and Kuen-Jer Tsai and Xiaofeng Jia},
  booktitle={International journal of molecular sciences},
  year={2015}
}
Delayed cerebral vasospasm is an important pathological feature of subarachnoid hemorrhage (SAH). The cause of vasospasm is multifactorial. Impairs nitric oxide availability and endothelial nitric oxide synthase (eNOS) dysfunction has been reported to underlie vasospasm. Memantine, a low-affinity uncompetitive N-methyl-d-aspartate (NMDA) blocker has been proven to reduce early brain injury after SAH. This study investigated the effect of memantine on attenuation of vasospasm and restoring eNOS… CONTINUE READING
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