Memantine: a review of its use in Alzheimer's disease.

  title={Memantine: a review of its use in Alzheimer's disease.},
  author={Dean M. Robinson and Gillian M. Keating},
  volume={66 11},
Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type. In well designed clinical trials, oral memantine, as monotherapy or in addition to a stable dose of… CONTINUE READING