Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse

  title={Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse},
  author={C. Parsons and A. Stoeffler and W. Danysz},
  • C. Parsons, A. Stoeffler, W. Danysz
  • Published 2007
  • Medicine, Psychology
  • Neuropharmacology
  • The neurotransmitter glutamate activates several classes of metabotropic receptor and three major types of ionotropic receptor--alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA). The involvement of glutamate mediated neurotoxicity in the pathogenesis of Alzheimer's disease (AD) is finding increasing scientific acceptance. Central to this hypothesis is the assumption that glutamate receptors, in particular of the NMDA type, are overactivated… CONTINUE READING
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    Paper Mentions

    Interventional Clinical Trial
    The purpose of this research study is to learn if the medication Memantine Hydrochloride (the study medication) can help adolescents and young adults with Down syndrome. Dr. Alberto… Expand
    ConditionsDown Syndrome, Intellectual Disability
    The fraction of activated N-methyl-d-Aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole
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    In vivo evidence for functional NMDA receptor blockade by memantine in rat hippocampal neurons
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    Mechanisms of NMDA receptor inhibition by memantine and ketamine
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    Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer's Disease
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    Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer’s disease
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    Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets.
    • 53
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    The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence
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    Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism
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    Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons
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    Modulation of learning processes by ionotropic glutamate receptor ligands.
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    Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons.
    • 70
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    Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
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    Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
    • 587
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    Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine.
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