• DOI:10.1016/j.neuropharm.2007.07.013
Corpus ID: 6599658

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse

@article{Parsons2007MemantineAN,
  title={Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse},
  author={C. Parsons and A. Stoeffler and W. Danysz},
  journal={Neuropharmacology},
  year={2007},
  volume={53},
  pages={699-723}
}

C. Parsons, A. Stoeffler, W. Danysz

Published 2007

Medicine, Psychology

Neuropharmacology

The neurotransmitter glutamate activates several classes of metabotropic receptor and three major types of ionotropic receptor--alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA). The involvement of glutamate mediated neurotoxicity in the pathogenesis of Alzheimer's disease (AD) is finding increasing scientific acceptance. Central to this hypothesis is the assumption that glutamate receptors, in particular of the NMDA type, are overactivated… CONTINUE READING

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