• Corpus ID: 73968628

Memantine: An oral NMDA antagonist for the treatment of moderate-to-severe Alzheimer's disease

@article{Feret2004MemantineAO,
  title={Memantine: An oral NMDA antagonist for the treatment of moderate-to-severe Alzheimer's disease},
  author={Brett Feret and Robert S. Dicks},
  journal={Formulary},
  year={2004},
  volume={39},
  pages={91-103}
}
Memantine (Namenda, Forest) is the newest medication to receive FDA approval for the treatment of Alzheimer's disease and the first to be approved with a moderate-to-severe indication. All previously approved Alzheimer's disease treatments belong to the cholinesterase inhibitor class and are approved with a mild-to-moderate indication. Memantine has been used for more than 10 years in Germany and features a novel mechanism of action: N-methyl-D-aspartate (NMDA) antagonism. It has been shown to… 
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