Memantine/gabapentin for the treatment of congenital nystagmus

  title={Memantine/gabapentin for the treatment of congenital nystagmus},
  author={James J. Corbett},
  journal={Current Neurology and Neuroscience Reports},
  • J. Corbett
  • Published 12 September 2007
  • Medicine
  • Current Neurology and Neuroscience Reports
Introduction: The problem of visual acuity degradation due to congenital idiopathic nystagmus (CIN) has largely been the province of the ophthalmologist, especially those with interest in pediatrics and ocular motility. Congenital nystagmus comes in many forms, and reports abound of the use of many medications in the treatment of individuals or small groups of patients with particular forms of nystagmus. A number of surgical and refractive procedures are used, but these modalities are not… 
Solubilization of gabapentin into HII mesophases.
In vitro transdermal delivery studies showed that the examined mesophases enabled a sustained release of GBP compared to its aqueous solution, and was more pronounced in the case of the hexagonal mesophase, compared to the lamellar one.


Surgical management of nystagmus.
  • John P. Lee
  • Medicine, Psychology
    Journal of the Royal Society of Medicine
  • 2002
NyStagmus surgery aims to reduce the amplitude of nystagmus with either improvement of visual acuity or a reduction of a bothersome head posture.
Current treatment of nystagmus
  • J. Rucker
  • Medicine
    Current treatment options in neurology
  • 2005
Treatment with 3,4-diaminopyridine and 4-aminopyrazine recently have been shown to be effective for downbeat nystagmus and Memantine now is available in the United States and is promising in the treatment of pendular nyStagmus.
The use of contact lenses to treat visually symptomatic congenital nystagmus
A double‐blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus
It is suggested that gabapentin may be an effective treatment for many patients with APN and that occasional patients with downbeat nystagmus will respond to gabAPentin or baclofen.