Melting characteristics of highly supercoiled DNA.

  title={Melting characteristics of highly supercoiled DNA.},
  author={Sumita Sen and Ansuman Lahiri and Rabindranath Majumdar},
  journal={Biophysical chemistry},
  volume={42 3},
The effect of high supercoil densities on the melting characteristics of a supercoiled DNA has been studied. It is found that although the melting temperature increases abruptly on converting a linear DNA merely into the relaxed circular form, it falls back substantially at high supercoil densities. It is further predicted, in such cases, that the number of melted base pairs should be significantly enhanced even at the physiological temperature, which may facilitate the binding of other… CONTINUE READING

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