Melphalan may be a more potent leukemogen than cyclophosphamide.

  title={Melphalan may be a more potent leukemogen than cyclophosphamide.},
  author={Mark H Greene and E. L. Harris and David M. Gershenson and George D. Malkasian and Lee Joseph Melton and A J Dembo and J. Michael Bennett and William Moloney and John Dunning Boice},
  journal={Annals of internal medicine},
  volume={105 3},
We have evaluated the relation between alkylating agents and leukemic disorders in 3363 1-year survivors of ovarian cancer who were treated in five randomized clinical trials and at two large medical centers. Overall, 28 patients developed acute nonlymphocytic leukemia (expected, 1.2) and 7 developed preleukemia. A 93-fold increased risk for acute nonlymphocytic leukemia was seen in 1794 women treated with chemotherapy; the incidence of leukemic disorders was 7.7/1000 women per year. Risk was… CONTINUE READING

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