Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.

@article{Chen2015MeloxicamII,
  title={Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.},
  author={Sifang Chen and Zhaoqi Zhang and Jingfeng Zhang},
  journal={Genetics and molecular research : GMR},
  year={2015},
  volume={14 4},
  pages={14548-60}
}
It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATP‑binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in the overcoming of multidrug resistance are unclear. In the present study, the ability of meloxicam, a COX-2-specific inhibitor to enhance doxorubicin… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
3 Extracted Citations
60 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 60 references

Anticancer Res

  • J Van Wijngaarden, E van Beek, G van Rossum, C van der Bent
  • 2007
Highly Influential
5 Excerpts

prostate cancer cells: Development of a new controlled released system

  • R O’Connor, M Heenan, L Connolly, A Larkin
  • Int. J. Pharm
  • 2004
Highly Influential
8 Excerpts

and risk of lung cancer

  • HJ Maeng, WJ Lee, QR Jin, J Chang
  • Lung Cancer
  • 2014
3 Excerpts

Similar Papers

Loading similar papers…