Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety

@article{Gates2005MeloxicamAR,
  title={Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety},
  author={Brian J. Gates and Trang T. Nguyen and Stephen M. Setter and Neal M. Davies},
  journal={Expert Opinion on Pharmacotherapy},
  year={2005},
  volume={6},
  pages={2117 - 2140}
}
The discovery of two distinct isoenzymes of COX has led to the development and clinical introduction of COX-2 inhibitors with increased selectivity onto the market. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class, and is a preferential inhibitor of COX-2, demonstrating effectiveness with anti-inflammatory, analgesic and antipyretic activity. Meloxicam is therapeutically utilised in the management of osteoarthritis and rheumatoid arthritis. Trials have examined… 

[Meloxicam in Russia: 20 years together].

The good tolerability of brand-name meloxicam (Movalis) is confirmed by a total of 120 spontaneous reports of the adverse events due to this drug, which were sent to the Federal Service for Health Supervision in December 2008 to July 2015.

Voriconazole Increases while Itraconazole Decreases Plasma Meloxicam Concentrations

Voriconazole increases plasma concentrations of meloxicam, whereas itraconazole, unexpectedly, decreases plasmameloxicam concentrations, possibly by impairing its absorption.

An old friend: 25 years of meloxicam use in Russia.

A series of large-scale, well-organized randomized controlled trials and observational post-registration studies have confirmed the good efficacy and low incidence of adverse reactions when using meloxicam.

Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration.

Single and Multiple-Dose Pharmacokinetics of Meloxicam After Oral Administration to the Rabbit (Oryctolagus cuniculus)

Meloxicam administered at 0.2 mg/kg p.o. daily for 10 day was well tolerated by the rabbits, and a higher dose may be required for optimum effects, this would require efficacy and safety studies in this species.

PHARMACOKINETIC DRUG-DRUG INTERACTIONS EVALUATION OF MELOXICAM WITH SELECTED CO-PRESCRIBED DRUGS

Meloxicam in healthy human volunteers from Pakistan was evaluated and then potential pharmacokinetic drug-drug interaction of meloxicam with selected co-prescribed drugs i.e. omeprazole and fluconazole was investigated, showing an increase in Cmax ofmeloxicam.

Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: Potential for emergency contraception

The findings of this pilot study suggest that the administration of meloxicam 30 mg/d for 5 consecutive days during the late follicular phase is effective, safe, and may be an alternative to levonorgestrel for emergency contraception.

The effect of the withdrawal of rofecoxib on prescribing patterns of COX-2 inhibitors in Scotland.

Examination of the effect of the withdrawal of rofecoxib on the prescription of other COX-2 inhibitors and nonselective nonsteroidal anti-inflammatory drugs in Scotland found prescribers appear to have interpreted this effect to be class specific.

Pharmacokinetics of 3 formulations of meloxicam in cynomolgus macaques (Macaca fascicularis).

The results indicate that the sustained-release formulation of meloxicam can achieve an adequate steady-state plasma concentration for 2 to 3 d in nonhuman primates, with waxing and waning levels associated with daily dosing.

Single dose oral meloxicam for acute postoperative pain in adults.

It is concluded that in the absence of evidence of efficacy, at present, for oral meloxicam in acute postoperative pain, its use in this indication is not justified.
...

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