Melittin selectively activates capsaicin-sensitive primary afferent fibers.

  title={Melittin selectively activates capsaicin-sensitive primary afferent fibers.},
  author={Hong Kee Shin and Jin Hyuk Kim},
  volume={15 11},
Whole bee venom (WBV)-induced pain model has been reported to be very useful for the study of pain. However, the major constituent responsible for the production of pain by WBV is not apparent. Intraplantar injection of WBV and melittin dramatically reduced mechanical threshold, and increased flinchings and paw thickness. In behavioral experiments, capsaicin pretreatment almost completely prevented WBV- and melittin-induced reduction of mechanical threshold and flinchings. Intraplantar… CONTINUE READING

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