Melittin promotes exocytosis in neuroendocrine cells through the activation of phospholipase A2

@article{Vitale2010MelittinPE,
  title={Melittin promotes exocytosis in neuroendocrine cells through the activation of phospholipase A2},
  author={Nicolas Vitale and Dani{\`e}le Thiers{\'e} and M Bader},
  journal={Regulatory Peptides},
  year={2010},
  volume={165},
  pages={111-116}
}
Regulated exocytosis requires the formation of trans-SNARE complexes that assemble at the interface between vesicles and the plasma membrane. Recent evidence has also highlighted the importance of lipid dynamic in this process. For instance, small cone-shaped lipids generating membrane curvature of the plasma membrane are synthesized at the exocytotic sites. Among those lipids, phosphatidic acid (PA) synthesized through the activity of phospholipase D (PLD) has been recently shown to be… CONTINUE READING