Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway.

@article{Liu2008MelittinPL,
  title={Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway.},
  author={Shujing Liu and Mei Yu and Ying He and Lin Xiao and Fang Wang and Changcheng Song and Shuhan Sun and Changquan Ling and Zhiheng Xu},
  journal={Hepatology},
  year={2008},
  volume={47 6},
  pages={1964-73}
}
UNLABELLED Melittin, a water-soluble toxic peptide derived from bee venom of Apis mellifera was reported to have inhibitory effects on hepatocellular carcinoma (HCC). However, its role in antimetastasis and the underlying mechanism remains elusive. By utilizing both HCC cell lines and an animal model based assay system, we found that Rac1, which has been shown to be involved in cancer cell metastasis, is highly expressed in aggressive HCC cell lines and its activity correlated with cell… CONTINUE READING

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