Melittin increases AMPA receptor affinity in rat brain synaptoneurosomes.

  title={Melittin increases AMPA receptor affinity in rat brain synaptoneurosomes.},
  author={J Bernard and Chantale Chabot and J W Gagne and Michel Baudry and Guy Massicotte},
  journal={Brain research},
  volume={671 2},
Recent experimental evidence suggests that phospholipase-induced changes in binding properties of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of glutamate receptors account for the increase in synaptic response observed in long-term potentiation (LTP). In the present study, we report that treatment of rat telencephalic synaptoneurosomes with the bee venom peptide melittin, a potent activator of endogenous phospholipases, increased [3H]AMPA binding to the AMPA… CONTINUE READING
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