Melittin cardiotoxicity in cultured mouse cardiac myocytes and its correlation with calcium overload.

@article{Okamoto1995MelittinCI,
  title={Melittin cardiotoxicity in cultured mouse cardiac myocytes and its correlation with calcium overload.},
  author={Tadashi Okamoto and Hiroko Isoda and Naoto Kubota and Kyoya Takahata and Takashi Takahashi and Takuya Kishi and Tomoe Y. Nakamura and Yukio Muromachi and Yukari Matsui and K. Goshima},
  journal={Toxicology and applied pharmacology},
  year={1995},
  volume={133 1},
  pages={150-63}
}
Venom from the honey bee Apis mellifera induces cardiovascular dysfunction. We studied which constituent(s) of the venom induces cardiotoxicity and how, using cultured cardiac myocytes from mouse fetuses. Among the venom constituents, only melittin caused contractile and morphological effects; other peptides, such as apamin and mastparan; enzymes, such as phospholipase A2; and low-molecular-weight compounds, such as histamine and dopamine, did not. Treatment with 4.5 micrograms/ml melittin… CONTINUE READING