Melflufen - a peptidase-potentiated alkylating agent in clinical trials.

  title={Melflufen - a peptidase-potentiated alkylating agent in clinical trials.},
  author={Malin Wickstr{\"o}m and Peter Nygren and Rolf Larsson and Johan Harmenberg and Jakob Lindberg and Per Sj{\"o}berg and Markus Jerling and Fredrik Lehmann and Paul Richardson and Kenneth Anderson and Dharminder Chauhan and Joachim Gullbo},
Aminopeptidases like aminopeptidase N (APN, also known as CD13) play an important role not only in normal cellular functioning but also in the development of cancer, including processes like tumor cell invasion, differentiation, proliferation, apoptosis, motility, and angiogenesis. An increased expression of APN has been described in several types of human malignancies, especially those characterized by fast-growing and aggressive phenotypes, suggesting APN as a potential therapeutic target… 

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