Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity

@article{Niederhafner2010MelectinMT,
  title={Melectin MAPs: the influence of dendrimerization on antimicrobial and hemolytic activity},
  author={P. Niederhafner and L. Bedn{\'a}rov{\'a} and M. Budĕs̆ı́nsk{\'y} and M. {\vS}afař{\'i}k and S. Ehala and J. Je{\vz}ek and Lenka Borovi{\vc}kov{\'a} and V. Fučík and V. {\vC}eřovsk{\'y} and J. Slaninov{\'a}},
  journal={Amino Acids},
  year={2010},
  volume={39},
  pages={1553-1561}
}
The recently described antimicrobial peptide melectin (MEP, GFLSILKKVLPKVMAHMK-NH2) exhibits high antimicrobial activity against Gram-positive and Gram-negative bacteria. Here we describe the synthesis and biological activities of 23 new analogues of MEP. We studied the influence of dimerization and tetramerization (MAP-constructs of MEP) on the antimicrobial and hemolytic activities, as well as the role of Met in positions 14 and 17 of the peptide chain. Oxidation of the Met to Met(O) and Met… Expand
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